Description

tert-Butyl 3-((3-Iodo-6-(Pyrrolidin-1-Yl)Pyridin-2-Yloxy)Methyl)Pyrrolidine-1-Carboxylate CAS NO 1228665-81-3 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure with a protected amine group. This compound is specifically engineered for use in sophisticated organic synthesis, particularly in the construction of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and drug discovery programs. The molecule's design offers a versatile scaffold for further functionalization in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Organic Synthesis Reagent: Used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of the iodine substituent, enabling further molecular diversification.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.

Basic Information

Product Name	tert-Butyl 3-((3-Iodo-6-(Pyrrolidin-1-Yl)Pyridin-2-Yloxy)Methyl)Pyrrolidine-1-Carboxylate
CAS No.	1228665-81-3
Molecular Formula	C19H28IN3O3
Molecular Weight	473.35 g/mol
Synonyms	1-Boc-3-((3-iodo-6-(pyrrolidin-1-yl)pyridin-2-yloxy)methyl)pyrrolidine; tert-Butyl 3-[[[3-iodo-6-(1-pyrrolidinyl)-2-pyridinyl]oxy]methyl]-1-pyrrolidinecarboxylate; 1-Pyrrolidinecarboxylic acid, 3-[[[3-iodo-6-(1-pyrrolidinyl)-2-pyridinyl]oxy]methyl]-, 1,1-dimethylethyl ester; 3-((3-Iodo-6-(pyrrolidin-1-yl)pyridin-2-yloxy)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-protected iodo-pyridyl-pyrrolidine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-((3-Iodo-6-(Pyrrolidin-1-Yl)Pyridin-2-Yloxy)Methyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and research-grade material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.