Description

3-Allyl-6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridine is a high-value, organosilicon-protected fluoropyridine derivative, serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its molecular architecture, featuring a fluoropyridine core, a pyrrolidine ring, and a tert-butyldimethylsilyl (TBDMS) protecting group, makes it indispensable for constructing complex bioactive molecules. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable fluoropyridine and allyl groups.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides and pesticides that utilize fluorinated heterocycles for enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating novel nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the synthesis of fluorescent or affinity probes for studying biological targets and pathways.
• Process Chemistry Scale-up: A validated intermediate for the kilogram-scale production of development compounds under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	3-Allyl-6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridine
CAS No.	1228665-48-2
Molecular Formula	C18H29FN2OSi
Molecular Weight	344.52 g/mol
Synonyms	2-Fluoro-3-allyl-6-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 3-Allyl-6-(3-((TBDMS-Oxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridine; 1-(6-Allyl-5-fluoro-2-pyridinyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyrrolidine; tert-Butyl((1-(6-allyl-5-fluoropyridin-2-yl)pyrrolidin-3-yl)methoxy)dimethylsilane; TBDMS-protected fluoropyridine pyrrolidine intermediate
EINECS	Contact for details

Quality Control

Every batch of 3-Allyl-6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure high purity and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere such as argon or nitrogen to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.