Description

Methyl 2-Chloro-6-Piperazin-1-Ylisonicotinate CAS NO 1227954-92-8 is a high-purity, functionalized pyridine derivative serving as a critical advanced pharmaceutical intermediate. This compound matters for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. Pharmaceutical R&D and manufacturing organizations need this precise chemical to develop and scale up production of new drug candidates, ensuring process reliability and final product quality.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Kinase Inhibitor Development: Core scaffold in the research and production of targeted kinase inhibitor therapies for oncology and inflammatory diseases.
• Chemical Synthesis: Versatile reagent for constructing complex heterocyclic systems in medicinal chemistry and process development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Academic & Industrial R&D: Used in research laboratories for exploring new chemical entities and biological pathways.

Basic Information

Product Name	Methyl 2-Chloro-6-Piperazin-1-Ylisonicotinate
CAS No.	1227954-92-8
Molecular Formula	C11H14ClN3O2
Molecular Weight	255.70 g/mol
Synonyms	Methyl 2-chloro-6-(piperazin-1-yl)isonicotinate; 2-Chloro-6-(piperazin-1-yl)isonicotinic acid methyl ester; 2-Chloro-6-piperazin-1-yl-isonicotinic acid methyl ester; Methyl 2-chloro-6-(1-piperazinyl)isonicotinate; Methyl 2-chloro-6-(piperazin-1-yl)pyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2-chloro-6-(1-piperazinyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-6-Piperazin-1-Ylisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.