Description

3-(Bromomethyl)-2-(Trifluoromethyl)Pyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive bromomethyl group and a stable trifluoromethyl substituent, makes it an indispensable reagent for introducing functional complexity into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel pyridine-based ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials that require specific fluorinated aromatic components.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an excellent electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Derivatization for Analytical Standards: Used to prepare reference standards and metabolites for analytical method development and regulatory testing in life sciences.

Basic Information

Item	Detail
Product Name	3-(Bromomethyl)-2-(Trifluoromethyl)Pyridine
CAS No.	1227602-81-4
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	2-(Trifluoromethyl)-3-(bromomethyl)pyridine; 3-Bromomethyl-2-trifluoromethylpyridine; 2-Trifluoromethyl-3-pyridinemethanol, bromide; Pyridine, 3-(bromomethyl)-2-(trifluoromethyl)-; (2-Trifluoromethyl-3-pyridyl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of 3-(Bromomethyl)-2-(Trifluoromethyl)Pyridine is manufactured and tested under strict quality management systems. We guarantee high-purity material suitable for demanding research and scale-up applications. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.