Description

2,5-Difluoropyridine-4-Carboxaldehyde is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and an aldehyde group, which allows for precise molecular modifications and the introduction of complexity into target structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts due to its electron-withdrawing and coordinating properties.
• Material Science Research: Serves as a monomer or functionalizing agent in the synthesis of advanced polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Utilized to create fluorescent tags, affinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis and R&D: A valuable scaffold for contract research organizations and academic labs exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	2,5-Difluoropyridine-4-Carboxaldehyde
CAS No.	1227602-08-5
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	4-Formyl-2,5-difluoropyridine; 2,5-Difluoroisonicotinaldehyde; 2,5-Difluoropyridine-4-carbaldehyde; 2,5-Difluoro-4-pyridinecarboxaldehyde; 4-Pyridinecarboxaldehyde, 2,5-difluoro-; 1227602-08-5 (CAS); 2,5-Difluoro-4-formylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoropyridine-4-Carboxaldehyde is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.