Description

3-Bromo-5-(trifluoromethyl)-2-pyridinecarboxaldehyde is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive aldehyde group with bromine and trifluoromethyl substituents on the pyridine ring, enabling precise molecular construction. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with enhanced properties.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient pyridine core.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Derivatization & Functionalization: The aldehyde group allows for further transformations into acids, alcohols, amines, and heterocycles via condensation or reduction reactions.

Basic Information

Product Name	3-Bromo-5-(trifluoromethyl)-2-pyridinecarboxaldehyde
CAS No.	1227601-42-4
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.99 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)picolinaldehyde; 2-Pyridinecarboxaldehyde, 3-bromo-5-(trifluoromethyl)-; 3-Bromo-5-trifluoromethylpyridine-2-carbaldehyde; 3-Bromo-5-(trifluoromethyl)-2-formylpyridine; 3-Bromo-5-(trifluoromethyl)picolinaldehyde; 3-Bromo-5-(trifluoromethyl)pyridine-2-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(trifluoromethyl)-2-pyridinecarboxaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.