Description

4-Bromo-3-Fluoro-2-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on expanding fluorinated compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	4-Bromo-3-Fluoro-2-(Trifluoromethyl)Pyridine
CAS No.	1227600-30-7
Molecular Formula	C6H2BrF4N
Molecular Weight	243.99 g/mol
Synonyms	2-(Trifluoromethyl)-4-bromo-3-fluoropyridine; 4-Bromo-3-fluoro-2-trifluoromethylpyridine; 3-Fluoro-4-bromo-2-(trifluoromethyl)pyridine; Pyridine, 4-bromo-3-fluoro-2-(trifluoromethyl)-; 1227600-30-7; 4-Bromo-3-fluoro-α,α,α-trifluoro-2-picoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluoro-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.