Description

4-Chloro-2-Fluoro-3-Methylpyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom chemical synthesis and scale-up projects under cGMP or ISO standards.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Methylpyridine
CAS No.	1227598-39-1
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	2-Fluoro-4-chloro-3-methylpyridine; 3-Methyl-4-chloro-2-fluoropyridine; 4-Chloro-2-fluoro-3-picoline; 2-Fluoro-3-methyl-4-chloropyridine; 4-Chloro-2-fluoro-3-methylpyridine (primary); Pyridine, 4-chloro-2-fluoro-3-methyl-; 1227598-39-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Methylpyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards. Custom purity grades, including research and GMP grades, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.