Description

5-Chloro-2-(Chloromethyl)-3-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated pyridines.
• Ligand and Catalyst Development: Used to create sophisticated nitrogen-containing ligands for transition metal catalysis in fine chemical manufacturing.
• Material Science Research: Intermediate for synthesizing functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for proprietary client projects requiring specific halogenated heterocycles.

Basic Information

Product Name	5-Chloro-2-(Chloromethyl)-3-Fluoropyridine
CAS No.	1227585-36-5
Molecular Formula	C6H4Cl2FN
Molecular Weight	180.01 g/mol
Synonyms	2-(Chloromethyl)-5-chloro-3-fluoropyridine; 3-Fluoro-5-chloro-2-chloromethylpyridine; 5-Chloro-3-fluoro-2-(chloromethyl)pyridine; 2-Chloromethyl-5-chloro-3-fluoropyridine; Pyridine, 5-chloro-2-(chloromethyl)-3-fluoro-; (Chloromethyl)(5-chloro-3-fluoropyridin-2-yl)
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-(Chloromethyl)-3-Fluoropyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.