Description

4-Iodo-6-Trifluoromethyl-Pyridin-2-Ylamine is a high-value, multi-functional pyridine derivative featuring both iodine and trifluoromethyl substituents. This compound is a critical pharmaceutical intermediate and organic building block prized for its unique reactivity and ability to modulate the physicochemical properties of target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive iodo substituent, enabling efficient carbon-carbon bond formation.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) where its halogen and fluorine content can tune electronic properties.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological systems and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences industry.

Basic Information

Product Name	4-Iodo-6-Trifluoromethyl-Pyridin-2-Ylamine
CAS No.	1227581-86-3
Molecular Formula	C6H4F3IN2
Molecular Weight	288.01 g/mol
Synonyms	2-Amino-4-iodo-6-(trifluoromethyl)pyridine; 4-Iodo-6-(trifluoromethyl)pyridin-2-amine; 6-Trifluoromethyl-4-iodopyridin-2-amine; 2-Pyridinamine, 4-iodo-6-(trifluoromethyl)-; 4-Iodo-6-trifluoromethyl-2-aminopyridine; 4-Iodo-6-trifluoromethylpyridin-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-6-Trifluoromethyl-Pyridin-2-Ylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal purity and stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.