Description

4-Iodo-3-(Trifluoromethyl)Pyridin-2-Amine is a high-value, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both iodine and a trifluoromethyl group on the pyridine core, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists exploring functional organic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand Synthesis: Building block for creating specialized ligands in catalysis and coordination chemistry.
• Material Science: Intermediate in the development of organic electronic materials, such as OLEDs and semiconductors.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on expanding fluorinated compound libraries to improve drug-like properties.

Basic Information

Product Name	4-Iodo-3-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	1227581-85-2
Molecular Formula	C6H4F3IN2
Molecular Weight	288.01 g/mol
Synonyms	2-Amino-4-iodo-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-4-iodopyridin-2-amine; 4-Iodo-3-trifluoromethyl-2-pyridinamine; 2-Pyridinamine, 4-iodo-3-(trifluoromethyl)-; 4-Iodo-3-(trifluoromethyl)-2-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-3-(Trifluoromethyl)Pyridin-2-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if possible and opened with minimal exposure to ambient humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.