Description

5-Chloro-2-Fluoro-3-Methoxypyridine is a high-value, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen and methoxy substitution pattern makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Building block for synthesizing functionalized polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Used to create molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-Methoxypyridine
CAS No.	1227580-27-9
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	3-Methoxy-5-chloro-2-fluoropyridine; 2-Fluoro-5-chloro-3-methoxypyridine; 5-Chloro-2-fluoro-3-pyridinol methyl ether; 2-Fluoro-3-methoxy-5-chloropyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-3-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.