Description

2-Bromo-5-(Trifluoromethyl)Pyridine-3-Methanol is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both bromine and trifluoromethyl substituents, provides unique reactivity and physicochemical properties essential for developing novel compounds. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and electronic materials due to its aromatic core and halogen functionality.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Pyridine-3-Methanol
CAS No.	1227580-00-8
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	3-(Hydroxymethyl)-2-bromo-5-(trifluoromethyl)pyridine; (2-Bromo-5-(trifluoromethyl)pyridin-3-yl)methanol; 2-Bromo-5-trifluoromethyl-3-pyridinemethanol; 2-Bromo-5-(trifluoromethyl)-3-pyridinemethanol; 2-Bromo-5-(trifluoromethyl)nicotinyl alcohol
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-5-(Trifluoromethyl)Pyridine-3-Methanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) against established internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.