Description

6-Bromo-3-Fluoro-2-Trifluoromethyl-Pyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity, metabolic stability, and lipophilicity.
• Material Science: Building block for creating advanced organic electronic materials, including charge-transport materials, organic light-emitting diodes (OLEDs), and liquid crystals.
• Chemical Research & Development: Versatile scaffold for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and the exploration of new chemical spaces.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.

Basic Information

Product Name	6-Bromo-3-Fluoro-2-Trifluoromethyl-Pyridine
CAS No.	1227578-46-2
Molecular Formula	C7H2BrF4N
Molecular Weight	263.99 g/mol
Synonyms	2-Bromo-5-Fluoro-6-(Trifluoromethyl)Pyridine; 6-Bromo-3-Fluoro-2-(Trifluoromethyl)Pyridine; 2-(Trifluoromethyl)-6-Bromo-3-Fluoropyridine; Pyridine, 6-Bromo-3-Fluoro-2-(Trifluoromethyl)-; 1227578-46-2
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-Fluoro-2-Trifluoromethyl-Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.