Description

2-Bromo-3-Fluoro-4-Formylpyridine is a high-value, multi-functional heterocyclic building block characterized by its bromo, fluoro, and formyl substituents. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering precise control over regiochemistry and reactivity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Nucleophilic Substitution: The formyl group provides a site for condensation reactions, such as the formation of imines or hydrazones, for library synthesis.
• Fluorine Chemistry: The fluorine atom is utilized to modulate lipophilicity, metabolic stability, and bioavailability in drug design.

Basic Information

Product Name	2-Bromo-3-Fluoro-4-Formylpyridine
CAS No.	1227572-94-2
Molecular Formula	C6H3BrFNO
Molecular Weight	204.00 g/mol
Synonyms	4-Formyl-2-bromo-3-fluoropyridine; 3-Fluoro-2-bromo-4-pyridinecarboxaldehyde; 2-Bromo-3-fluoropyridine-4-carbaldehyde; 2-Bromo-3-fluoroisonicotinaldehyde; 2-Bromo-3-fluoro-4-pyridylcarboxaldehyde; 4-Aldehyde-2-bromo-3-fluoropyridine; Pyridine, 2-bromo-3-fluoro-4-formyl-
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoro-4-Formylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under inert atmosphere where appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.