Description

6-Methoxy-2-(Trifluoromethyl)Nicotinic Acid is a high-purity, synthetically valuable trifluoromethylated pyridine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for the development of novel active ingredients. It is primarily utilized by pharmaceutical R&D and agrochemical research organizations seeking to incorporate the unique physicochemical properties of the trifluoromethyl group into new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Research: Used as a building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialized ligands, catalysts, and organic electronic materials that benefit from its electron-withdrawing characteristics.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes and inhibitors used in biochemical and pharmacological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity fluorinated intermediates.

Basic Information

Product Name	6-Methoxy-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	1227516-90-6
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	2-(Trifluoromethyl)-6-methoxynicotinic acid; 6-Methoxy-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-methoxy-2-(trifluoromethyl)-; 6-Methoxy-2-trifluoromethylnicotinic acid; 2-Trifluoromethyl-6-methoxynicotinic acid; 6-Methoxy-α,α,α-trifluoro-2-picolinic acid; 1227516-90-6
EINECS	Contact for details

Quality Control

Our 6-Methoxy-2-(Trifluoromethyl)Nicotinic Acid is manufactured under cGMP (current Good Manufacturing Practice) conditions where applicable, ensuring batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC (for purity and impurity profile), NMR (for structural confirmation), and KF titration (for moisture content). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.