Description

2-(Bromomethyl)-3-Chloropyridine is a versatile halogenated pyridine derivative, serving as a key building block in advanced organic synthesis. Its bifunctional reactivity, featuring both bromomethyl and chloro substituents on the pyridine ring, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyridine moiety is a key structural component.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of organic electronic materials, metal-organic frameworks (MOFs), and other functional polymers.
• Cross-Coupling Reactions: The bromomethyl group is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce new carbon chains.
• Nucleophilic Substitution: The chloro and bromo groups allow for sequential, selective substitution reactions to create diverse chemical libraries.

Basic Information

Product Name	2-(Bromomethyl)-3-Chloropyridine
CAS No.	1227515-76-5
Molecular Formula	C6H5BrClN
Molecular Weight	206.47 g/mol
Synonyms	3-Chloro-2-(bromomethyl)pyridine; 2-Bromomethyl-3-chloropyridine; (3-Chloro-2-pyridinyl)methyl bromide; 3-Chloro-2-pyridinemethyl bromide; 2-Pyridinemethanol, 3-chloro-, bromide; 1227515-76-5; 3-Chloro-2-(bromomethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-(Bromomethyl)-3-Chloropyridine is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.