Description

2-Chloro-4-Fluoro-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, liquid crystals, and functional materials requiring specific halogenated aromatic systems.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex, fluorinated pyridine motifs into target molecules.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-(Trifluoromethyl)Pyridine
CAS No.	1227511-50-3
Molecular Formula	C6H2ClF4N
Molecular Weight	199.54 g/mol
Synonyms	2-Chloro-4-fluoro-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-chloro-4-fluoropyridine; Pyridine, 2-chloro-4-fluoro-5-(trifluoromethyl)-; 2-Chloro-4-fluoro-5-trifluoromethylpyridine; 1227511-50-3; 2-Chloro-4-fluoro-5-(trifluoromethyl)pyridine (CAS 1227511-50-3)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Production follows cGMP principles where applicable, and every batch is analyzed to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity confirmation, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.