Description

4-Chloro-2-Fluoro-6-Methylpyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which enables precise molecular modifications in the development of complex chemical entities. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing halogenated pyridine motifs into bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where its specific halogenation pattern contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological systems and mechanisms.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated heterocycles.

Basic Information

Product Name	4-Chloro-2-Fluoro-6-Methylpyridine
CAS No.	1227509-42-3
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	2-Fluoro-4-chloro-6-methylpyridine; 6-Methyl-4-chloro-2-fluoropyridine; 4-Chloro-2-fluoro-6-picoline; 2-Fluoro-4-chloro-6-picoline; Pyridine, 4-chloro-2-fluoro-6-methyl-; 1227509-42-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-6-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO-guided processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.