Description

4-Bromo-2-Hydroxy-5-(Trifluoromethyl)Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and trifluoromethyl substituents, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, herbicides, and pesticides, leveraging the biological activity of the pyridine core.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, functionalized polymers, and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex biaryl structures.

Basic Information

Product Name	4-Bromo-2-Hydroxy-5-(Trifluoromethyl)Pyridine
CAS No.	1227494-05-4
Molecular Formula	C6H3BrF3NO
Molecular Weight	241.99 g/mol
Synonyms	5-(Trifluoromethyl)-4-bromopyridin-2-ol; 4-Bromo-5-(trifluoromethyl)-2-pyridinol; 2-Hydroxy-4-bromo-5-(trifluoromethyl)pyridine; 4-Bromo-2-hydroxy-5-trifluoromethylpyridine; 4-Bromo-5-trifluoromethyl-2(1H)-pyridinone; 2-Pyridinol, 4-bromo-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Hydroxy-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.