Description

2-Amino-3-Bromo-4-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the physicochemical properties of target molecules, such as lipophilicity, metabolic stability, and binding affinity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-deficient pyridine core.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Fine Chemical Manufacturing: Utilized as a specialized intermediate in custom synthesis and contract manufacturing for high-value chemical products.

Basic Information

Item	Details
Product Name	2-Amino-3-Bromo-4-(Trifluoromethyl)Pyridine
CAS No.	1227489-63-5
Molecular Formula	C7H4BrF3N2
Molecular Weight	241.02 g/mol
Synonyms	3-Bromo-2-amino-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-amino-3-bromopyridine; 2-Pyridinamine, 3-bromo-4-(trifluoromethyl)-; 2-Amino-3-bromo-4-trifluoromethylpyridine; 3-Bromo-4-trifluoromethylpyridin-2-ylamine
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Bromo-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.