Description

4-Bromo-2-(Difluoromethoxy)-6-Methylpyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated pyridine structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of agrochemicals and small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to introduce specific bromine and difluoromethoxy functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its halogenated pyridine core.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Chemical Biology Probes: Utilized in the creation of tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	4-Bromo-2-(Difluoromethoxy)-6-Methylpyridine
CAS No.	1227184-58-8
Molecular Formula	C7H6BrF2NO
Molecular Weight	238.03 g/mol
Synonyms	2-(Difluoromethoxy)-4-bromo-6-methylpyridine; 4-Bromo-6-methyl-2-(difluoromethoxy)pyridine; 6-Methyl-4-bromo-2-(difluoromethoxy)pyridine; Pyridine, 4-bromo-2-(difluoromethoxy)-6-methyl-; 1227184-58-8
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethoxy)-6-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable and consistent performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure the container is kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.