Description

Amelparib CAS NO 1227156-72-0 is a potent and selective small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, a key target class in oncology research. This compound is crucial for advancing the development of novel cancer therapeutics, particularly for tumors with deficiencies in DNA repair pathways such as BRCA mutations. It is an essential research chemical for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on targeted cancer therapy, synthetic lethality studies, and preclinical drug discovery.

Application

• Oncology Research & Drug Discovery: Primary tool compound for investigating PARP inhibition mechanisms and synthetic lethality in various cancer cell lines.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and pharmacodynamics of PARP-targeted therapies.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new PARP inhibitors.
• Combination Therapy Studies: Research into synergistic effects when combined with other chemotherapeutic agents, radiation, or DNA-damaging drugs.
• Mechanistic Studies: Fundamental research on the role of PARP enzymes in DNA repair, genomic stability, and cellular metabolism.

Basic Information

Product Name	Amelparib
CAS No.	1227156-72-0
Molecular Formula	C19H20FN5O2
Molecular Weight	369.40 g/mol
Synonyms	2-Fluoro-5-[(4S)-4-(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]benzamide; (S)-2-Fluoro-5-(4-(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-yl)-N-(4-(morpholinomethyl)phenyl)benzamide; PARP Inhibitor; UNII-9J2F11D6LI; Research Compound 1227156-72-0
EINECS	Contact for details

Quality Control

Our Amelparib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.