Description

5-(3-(Trifluoromethyl)Phenyl)Pyridin-3-Amine CAS NO 1226168-85-9 is a high-value trifluoromethyl-substituted aromatic amine, a versatile building block prized for its ability to impart metabolic stability and lipophilicity to target molecules. This compound is essential for research and development in advanced organic synthesis, particularly in the creation of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is a critical intermediate for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the trifluoromethyl group into complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially kinase inhibitors, receptor modulators, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-(3-(Trifluoromethyl)Phenyl)Pyridin-3-Amine
CAS No.	1226168-85-9
Molecular Formula	C12H9F3N2
Molecular Weight	238.21 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]pyridin-3-amine; 3-Amino-5-(3-trifluoromethylphenyl)pyridine; 5-(3-Trifluoromethylphenyl)-3-pyridinamine; 3-Pyridinamine, 5-[3-(trifluoromethyl)phenyl]-; 1226168-85-9; 5-(α,α,α-Trifluoro-m-tolyl)nicotinamide (precursor); 5-(m-Trifluoromethylphenyl)-3-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-(3-(Trifluoromethyl)Phenyl)Pyridin-3-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.