Description

Loxo-101 CAS NO 1223403-58-4 is a high-purity, small molecule pharmaceutical intermediate and research chemical of significant interest in modern drug discovery. Its primary value lies in its role as a key building block for the synthesis of targeted therapeutic agents, particularly in oncology. This compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and advanced chemical synthesis facilities engaged in developing next-generation precision medicines.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for targeted cancer therapies.
• Kinase Inhibitor Research: Serves as a core scaffold or intermediate in the development and optimization of selective kinase inhibitors.
• Preclinical Drug Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead compound optimization.
• Biochemical Assay Development: Employed as a reference standard or tool compound in high-throughput screening and biochemical assays.
• Academic Research: Utilized in university and institutional laboratories for chemical biology studies and investigating novel signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	Loxo-101
CAS No.	1223403-58-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LOXO-101; Larotrectinib Intermediate; ARRY-470; Vitrakvi Intermediate; (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide; TRK Inhibitor Intermediate; LOXO101
EINECS	Contact for details

Quality Control

Every batch of Loxo-101 is manufactured and tested under strict quality management systems to ensure the highest standards of purity and consistency required for pharmaceutical research. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to protect the integrity of the material.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.