Description

5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is a high-value, heterocyclic boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and heterobiaryl structures in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new pesticides and herbicides with improved efficacy and selectivity.
• Material Science Precursor: Potential monomer or intermediate for creating organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probe Synthesis: Facilitates the creation of labeled compounds and molecular probes for studying biological pathways.
• Academic & Contract Research: Essential reagent for methodology development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1222533-84-7
Molecular Formula	C13H16BFN2O2
Molecular Weight	262.09 g/mol
Synonyms	5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-3-(pinacolatoboryl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 1222533-84-7; 5-Fluoro-3-borono-1H-pyrrolo[2,3-b]pyridine pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural integrity suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.