Description

8-Pivaloyl-5,6,7,8-Tetrahydro-1,8-Naphthyridine-3-Carbonitrile is a high-value, advanced pharmaceutical intermediate characterized by its unique naphthyridine core structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. Pharmaceutical R&D and manufacturing organizations need this material for developing next-generation drug candidates, where its specific functional groups enable precise molecular modifications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and oncology.
• Chemical Synthesis Building Block: Used in medicinal chemistry for constructing complex polycyclic frameworks and introducing the nitrile functional group for further derivatization.
• Research & Development (R&D): Serves as a key reagent in academic and industrial research laboratories for exploring new chemical entities and reaction pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules during process development.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	8-Pivaloyl-5,6,7,8-Tetrahydro-1,8-Naphthyridine-3-Carbonitrile
CAS No.	1222533-78-9
Molecular Formula	C15H19N3O
Molecular Weight	257.33 g/mol
Synonyms	8-Pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbonitrile; 5,6,7,8-Tetrahydro-8-(2,2-dimethylpropanoyl)-1,8-naphthyridine-3-carbonitrile; 3-Cyano-8-pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridine; 1,8-Naphthyridine-3-carbonitrile, 5,6,7,8-tetrahydro-8-(2,2-dimethyl-1-oxopropyl)-; Pivaloyltetrahydronaphthyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 8-Pivaloyl-5,6,7,8-Tetrahydro-1,8-Naphthyridine-3-Carbonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) documenting full specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.