Description

6-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused naphthyridine core structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for constructing complex molecular architectures with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space and improve drug-like properties.
• API Synthesis: Serves as a critical precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring the 1,8-naphthyridine scaffold.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing specialized, high-value compounds.

Basic Information

Product Name	6-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One
CAS No.	1222533-77-8
Molecular Formula	C9H7FN2O
Molecular Weight	178.16 g/mol
Synonyms	6-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one; 6-Fluoro-3,4-dihydro-1H-1,8-naphthyridin-2-one; 2(1H)-1,8-Naphthyridinone, 6-fluoro-3,4-dihydro-; 6-Fluoro-1,2,3,4-tetrahydro-[1,8]naphthyridin-2-one; 1222533-77-8; 6-Fluoro-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.