Description

p-Ncs-Bz-Dfo CAS NO 1222468-90-7 is a specialized chemical compound featuring a p-nitrocarbamoylbenzoyl (p-Ncs-Bz) group coupled to a deferoxamine (Dfo) backbone. This bifunctional chelator is engineered for the site-specific conjugation of radionuclides or therapeutic payloads to targeting vectors like antibodies and peptides. It is a critical intermediate for researchers and manufacturers in the radiopharmaceutical and targeted therapy sectors, enabling the development of next-generation diagnostic and therapeutic agents. The compound's design facilitates stable complexation with metals like Gallium-68 or Zirconium-89 for PET imaging and other medical applications.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing bifunctional chelators used in PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) imaging agents.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a functionalized linker for attaching cytotoxic drugs or imaging probes to monoclonal antibodies.
• Peptide-Based Theranostics: Used in the development of peptide conjugates for combined diagnostic imaging and targeted radiotherapy.
• Research & Development: A vital tool in academic and industrial labs for exploring novel targeted delivery systems and metal complexation chemistry.
• Molecular Probe Synthesis: Facilitates the creation of high-affinity probes for biological target identification and validation studies.
• Pre-clinical Development: Supports the early-stage development and optimization of novel radiometal-based therapeutics.

Basic Information

Product Name	p-Ncs-Bz-Dfo
CAS No.	1222468-90-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	p-Nitrocarbamoylbenzoyl-Deferoxamine; p-NCS-Bz-DFO; NCS-Bz-DFO; Bifunctional Chelator DFO Derivative; 4-Nitrobenzylcarbamoyl-Deferoxamine; DFO-p-NCS-Bz; Precursor for Zr-89/ Ga-68 Chelation; Deferoxamine-p-Nitrobenzyl Isothiocyanate Conjugate
EINECS	Contact for details

Quality Control

Our p-Ncs-Bz-Dfo is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.