Description

1-Trityl-1H-Imidazole-4-Carbonyl Chloride is a high-value, protected imidazole derivative where the trityl group shields the reactive nitrogen, and the carbonyl chloride moiety provides a versatile handle for further chemical transformations. This compound matters as a critical synthetic intermediate, enabling the controlled introduction of the imidazole pharmacophore into complex molecules under mild conditions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including kinase inhibitors and other heterocyclic-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides containing imidazole scaffolds.
• Peptide Mimetics & Bioconjugation: The activated carbonyl chloride group facilitates coupling reactions for creating imidazole-containing peptide analogs or protein conjugates.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	1-Trityl-1H-Imidazole-4-Carbonyl Chloride
CAS No.	1221885-49-9
Molecular Formula	C23H17ClN2O
Molecular Weight	372.85 g/mol
Synonyms	1-Trityl-1H-imidazole-4-carbonyl chloride; 1-(Triphenylmethyl)-1H-imidazole-4-carbonyl chloride; 4-(Chlorocarbonyl)-1-tritylimidazole; 1H-Imidazole-4-carbonyl chloride, 1-(triphenylmethyl)-; Trityl-protected imidazole-4-carbonyl chloride; 1-Tritylimidazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1-Trityl-1H-Imidazole-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.