Description

Ethyl 2-Chloro-4-(trifluoromethyl)nicotinate is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated and fluorinated nicotinate structure. This compound is essential for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging the trifluoromethyl group for enhanced bioactivity and stability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Building Block: Employed in organic synthesis for introducing the 2-chloro-4-(trifluoromethyl)pyridine moiety into more complex molecular architectures.
• Material Science Research: Potential use in the development of specialty chemicals and functional materials due to its unique fluorinated aromatic structure.

Basic Information

Product Name	Ethyl 2-Chloro-4-(Trifluoromethyl)Nicotinate
CAS No.	1221792-56-8
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.60 g/mol
Synonyms	Ethyl 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylate; 2-Chloro-4-(trifluoromethyl)nicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester; Ethyl 2-chloro-4-trifluoromethylnicotinate; 1221792-56-8; 2-Chloro-4-trifluoromethyl-nicotinic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Chloro-4-(Trifluoromethyl)Nicotinate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality system is designed to meet the rigorous standards required for pharmaceutical R&D and cGMP intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.