Description

3-Chloro-2-Methoxy-5-(Trifluoromethyl)-Isonicotinic Acid is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethyl and isonicotinic acid scaffold. This compound matters for its critical role in modern pharmaceutical and agrochemical research, where it serves as a versatile building block for synthesizing novel active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate fluorine-containing motifs for enhanced bioactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic & Industrial R&D: A valuable tool compound for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Chloro-2-Methoxy-5-(Trifluoromethyl)-Isonicotinic Acid
CAS No.	1221792-35-3
Molecular Formula	C8H5ClF3NO3
Molecular Weight	255.58 g/mol
Synonyms	3-Chloro-2-methoxy-5-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 3-chloro-2-methoxy-5-(trifluoromethyl)-; 3-Chloro-2-methoxy-5-trifluoromethylisonicotinic acid; 3-Chloro-2-methoxy-5-(trifluoromethyl)-4-pyridinecarboxylic acid; 1221792-35-3; 3-Chloro-2-methoxy-5-trifluoromethyl-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Methoxy-5-(Trifluoromethyl)-Isonicotinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.