Description

2-{3-[2-Amino-5-(Trifluoromethyl)-3-Pyridinyl]-2-Propynyl}-1H-Isoindole-1,3(2H)-Dione is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining a trifluoromethylpyridine and a phthalimide moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting specific enzyme pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its trifluoromethyl and amino functional groups.
• Protease Inhibitor Development: The phthalimide group can serve as a recognition element in the design of enzyme inhibitors.
• Kinase Inhibitor Synthesis: The aminopyridine core is a common pharmacophore in kinase-targeted drug discovery programs.
• Labeled Compound Precursor: Can be used to synthesize isotopically labeled (e.g., deuterated, C13) versions for pharmacokinetic and metabolic studies.
• Chemical Biology Probes: Useful for creating tool compounds to study biological pathways and protein function.

Basic Information

Item	Details
Product Name	2-{3-[2-Amino-5-(Trifluoromethyl)-3-Pyridinyl]-2-Propynyl}-1H-Isoindole-1,3(2H)-Dione
CAS No.	1221792-28-4
Molecular Formula	C17H10F3N3O2
Molecular Weight	345.28 g/mol
Synonyms	2-(3-(2-Amino-5-(trifluoromethyl)pyridin-3-yl)prop-2-yn-1-yl)isoindoline-1,3-dione; 2-[3-(2-Amino-5-trifluoromethyl-3-pyridyl)-2-propynyl]phthalimide; 2-(3-(2-Amino-5-(trifluoromethyl)pyridin-3-yl)prop-2-ynyl)-1H-isoindole-1,3(2H)-dione; N-(3-(2-Amino-5-(trifluoromethyl)pyridin-3-yl)prop-2-yn-1-yl)phthalimide; CAS 1221792-28-4
EINECS	Contact for details

Quality Control

Our 2-{3-[2-Amino-5-(Trifluoromethyl)-3-Pyridinyl]-2-Propynyl}-1H-Isoindole-1,3(2H)-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.