Description

2-(Trifluoromethoxy)Pyridin-3-Amine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted pyridine core offers enhanced metabolic stability and lipophilicity, making it indispensable for creating novel molecular entities. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic components.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeling reagents in biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.

Basic Information

Product Name	2-(Trifluoromethoxy)Pyridin-3-Amine
CAS No.	1221171-94-3
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	3-Amino-2-(trifluoromethoxy)pyridine; 2-(Trifluoromethoxy)-3-pyridinamine; 3-Pyridinamine, 2-(trifluoromethoxy)-; 2-Trifluoromethoxypyridin-3-ylamine; 2-(Trifluoromethoxy)-3-aminopyridine
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.