Description

5-(Trifluoromethoxy)Pyridin-2-Amine is a high-value pyridine derivative featuring a trifluoromethoxy substituent, a key structural motif prized for its ability to modulate the physicochemical properties of active molecules. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of complex, fluorinated target molecules for various industrial applications.

Basic Information

Product Name	5-(Trifluoromethoxy)Pyridin-2-Amine
CAS No.	1221171-88-5
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	2-Amino-5-(trifluoromethoxy)pyridine; 5-(Trifluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 5-(trifluoromethoxy)-; 5-Trifluoromethoxypyridin-2-amine; 2-Amino-5-trifluoromethoxypyridine; 5-(Trifluoromethoxy)-2-aminopyridine; 5-(Trifluoromethoxy)pyridin-2-ylamine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.