Description

Methyl 5-Bromo-2-(Dimethylamino)Nicotinate CAS NO 1220419-54-4 is a high-purity, advanced pharmaceutical intermediate characterized by its brominated nicotinate core and dimethylamino functional group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and neurological research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing molecular libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Organic Synthesis: Used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to introduce functionalized pyridine motifs into target molecules.
• Agrochemical Development: Employed in the research and synthesis of new crop protection agents and herbicides.
• Material Science: Potential intermediate for the synthesis of specialty chemicals, ligands, or functional materials.

Basic Information

Product Name	Methyl 5-Bromo-2-(Dimethylamino)Nicotinate
CAS No.	1220419-54-4
Molecular Formula	C9H11BrN2O2
Molecular Weight	259.10 g/mol
Synonyms	5-Bromo-2-(dimethylamino)nicotinic acid methyl ester; Methyl 5-bromo-2-(dimethylamino)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-bromo-2-(dimethylamino)-, methyl ester; 2-(Dimethylamino)-5-bromonicotinic acid methyl ester; 5-Bromo-N,N-dimethyl-3-(methoxycarbonyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-(Dimethylamino)Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.