Description

3-Chloro-2-(1-Piperidinyl)-5-(Trifluoromethyl)-Pyridine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a halogenated pyridine core substituted with a piperidine ring and a trifluoromethyl group, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, insecticides, and fungicides, leveraging the bioactivity of the pyridine and trifluoromethyl motifs.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging reagent in the design of chemical probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes under cGMP conditions.

Basic Information

Product Name	3-Chloro-2-(1-Piperidinyl)-5-(Trifluoromethyl)-Pyridine
CAS No.	1219967-90-4
Molecular Formula	C11H12ClF3N2
Molecular Weight	264.68 g/mol
Synonyms	3-Chloro-2-piperidin-1-yl-5-(trifluoromethyl)pyridine; 2-Chloro-6-(piperidin-1-yl)-4-(trifluoromethyl)pyridine; 3-Chloro-2-(piperidin-1-yl)-5-(trifluoromethyl)pyridine; 3-Chloro-2-piperidino-5-trifluoromethylpyridine; 2-(1-Piperidinyl)-3-chloro-5-(trifluoromethyl)pyridine; 3-Chloro-2-piperidin-1-yl-5-trifluoromethyl-pyridine; 3-Chloro-2-(piperidin-1-yl)-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-(1-Piperidinyl)-5-(Trifluoromethyl)-Pyridine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to traceability and regulatory support (e.g., for REACH, TSCA) makes us a reliable partner for global R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.