Description

3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxy-5-Methyluridine is a chemically modified nucleoside derivative, serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its unique azido and acetyl-protected functional groups, which enable precise chemical transformations for creating novel therapeutic agents. This high-purity building block is essential for researchers and manufacturers in the fields of antiviral drug discovery, oligonucleotide synthesis, and prodrug development, where reliable quality and structural integrity are paramount.

Application

• Key Intermediate in Antiviral Prodrug Synthesis: A vital precursor in the development of nucleoside analog prodrugs, particularly for antiviral therapies targeting viruses like hepatitis and herpes.
• Oligonucleotide and Antisense Technology: Used in the solid-phase synthesis of modified oligonucleotides for research into gene silencing, antisense therapies, and diagnostic probes.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies by allowing controlled modifications to the sugar moiety of nucleoside scaffolds.
• Click Chemistry Substrate: The azido group makes it a valuable substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating bioconjugation and labeling.
• Academic and Industrial R&D: Serves as a high-value research chemical in university laboratories and corporate R&D centers exploring novel nucleoside-based pharmaceuticals.
• Precursor for Further Functionalization: The acetyl protecting groups allow for selective deprotection and subsequent introduction of other pharmacophores.

Basic Information

Item	Detail
Product Name	3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxy-5-Methyluridine
CAS No.	1219963-42-4
Molecular Formula	C14H17N5O7
Molecular Weight	367.32 g/mol
Synonyms	2'-Azido-2'-deoxy-5-methyluridine 3',5'-diacetate; 5-Methyl-2'-azido-2'-deoxyuridine 3',5'-di-O-acetate; 1-[(2R,3S,4R,5R)-3-Azido-5-(hydroxymethyl)-4-(acetyloxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 3'-acetate; AZT-MU Diacetate; 2'-N3-5-Me-2'-dUrd 3',5'-di-OAc
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxy-5-Methyluridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.