Description

1-(Methoxymethyl)-3-(Trifluoromethyl)-1H-Pyrazol-4-Ylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters because it enables the efficient construction of complex molecules through pivotal cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing trifluoromethylpyrazole motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage its unique heterocyclic boronic acid structure.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile coupling partner with aryl/heteroaryl halides to form new carbon-carbon bonds under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for high-throughput screening in lead identification and optimization programs.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	1-(Methoxymethyl)-3-(Trifluoromethyl)-1H-Pyrazol-4-Ylboronic Acid
CAS No.	1218790-73-8
Molecular Formula	C7H8BF3N2O3
Molecular Weight	236.96 g/mol
Synonyms	1-(Methoxymethyl)-3-(trifluoromethyl)-1H-pyrazole-4-boronic acid; 4-Borono-1-(methoxymethyl)-3-(trifluoromethyl)-1H-pyrazole; [1-(Methoxymethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]boronic acid; 1H-Pyrazole-4-boronic acid, 1-(methoxymethyl)-3-(trifluoromethyl)-; 3-Trifluoromethyl-1-methoxymethyl-1H-pyrazole-4-boronic acid; 1-Methoxymethyl-3-trifluoromethyl-1H-pyrazole-4-boronic acid; B-[1-(Methoxymethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]boronic acid
EINECS	Contact for details

Quality Control

Our 1-(Methoxymethyl)-3-(Trifluoromethyl)-1H-Pyrazol-4-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.