Description

2-Isobutoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its unique pyridine core and boronic acid functionality make it a versatile reagent for targeted molecular synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a pivotal boronic acid reagent for forming carbon-carbon bonds between aromatic rings, a fundamental step in creating complex organic architectures.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and novel polymers where specific electronic properties are required.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of molecular probes and library compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Isobutoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	1218790-68-1
Molecular Formula	C11H15BF3NO3
Molecular Weight	277.05 g/mol
Synonyms	5-(Trifluoromethyl)-2-isobutoxypyridine-3-boronic acid; 2-(2-Methylpropoxy)-5-(trifluoromethyl)pyridine-3-boronic acid; 3-Borono-2-isobutoxy-5-(trifluoromethyl)pyridine; (2-Isobutoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid; B-[2-(2-Methylpropoxy)-5-(trifluoromethyl)-3-pyridinyl]boronic acid; 1218790-68-1; Pyridine-3-boronic acid, 2-isobutoxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Isobutoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.