Description

Apatinib Mesylate CAS NO 1218779-75-9 is a small molecule tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR-2). This compound is of significant commercial and clinical interest for its potent anti-angiogenic properties, which are critical in halting tumor growth and metastasis. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and production of targeted cancer therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the formulation of targeted anti-cancer drugs.
• Oncology Research: Used as a critical reference standard and investigational compound in preclinical and clinical studies focusing on VEGFR-2 inhibition.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and in-vitro assays to study angiogenesis and kinase signaling pathways.
• Drug Discovery & Development: A key intermediate for medicinal chemists working on synthesizing novel TKI analogs and prodrugs.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and pharmacology research.
• GMP Manufacturing: Supplied as a starting material or intermediate for the cGMP-compliant production of finished dosage forms.

Basic Information

Product Name	Apatinib Mesylate
CAS No.	1218779-75-9
Molecular Formula	C24H25N5O3 • CH4O3S
Molecular Weight	493.56 g/mol (mesylate salt)
Synonyms	YN968D1 Mesylate; Rivoceranib Mesylate; Apatinib (Mesylate salt); N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide monomethanesulfonate; Apatinib Methanesulfonate
EINECS	Contact for details

Quality Control

Our Apatinib Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.