Description

S-3-(Aminomethyl)-1-n-Cbz-Piperidine-Hcl is a high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its protected amine and carboxybenzyl (Cbz) functional groups, which are essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• Peptidomimetics Synthesis: Used to introduce constrained piperidine scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities and optimize lead compounds.
• Custom Synthesis: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	S-3-(Aminomethyl)-1-n-Cbz-Piperidine-Hcl
CAS No.	1217774-98-5
Molecular Formula	C15H23ClN2O2
Molecular Weight	298.81 g/mol
Synonyms	(S)-1-((Benzyloxy)carbonyl)-3-(aminomethyl)piperidine hydrochloride; (S)-1-Cbz-3-(aminomethyl)piperidine HCl; (S)-3-(Aminomethyl)-1-[(benzyloxy)carbonyl]piperidine hydrochloride; 1-[(Benzyloxy)carbonyl]-3-(aminomethyl)piperidine hydrochloride (S-enantiomer); (S)-1-N-Cbz-3-(aminomethyl)piperidine hydrochloride; (S)-N-Cbz-3-piperidinemethylamine hydrochloride; (3S)-1-[(Phenylmethoxy)carbonyl]-3-piperidinemethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our S-3-(Aminomethyl)-1-n-Cbz-Piperidine-Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.