Description

(R)-2-Methylbutyric Acid Chloride-D3 is a chiral, deuterated acid chloride derivative, specifically the (R)-enantiomer of 2-methylbutyryl chloride with three deuterium atoms. This compound is a high-value synthetic building block prized for its role in introducing the (R)-2-methylbutyryl moiety into target molecules while providing a stable isotopic label for tracking and analytical purposes. It is primarily utilized by pharmaceutical researchers and agrochemical developers engaged in the synthesis of novel active ingredients, metabolic studies, and the development of deuterated drug candidates.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly for deuterium-labeled drug candidates.
• Metabolic & Pharmacokinetic Studies: Serves as a precursor for internal standards and probes in LC-MS and GC-MS analysis due to its stable deuterium labels.
• Agrochemical Synthesis: Used in the production of chiral, high-performance pesticides and herbicides.
• Asymmetric Synthesis: Employed in acylations and other reactions where the chiral (R)-configuration is critical for stereoselectivity.
• Fine Chemical & Flavor/Fragrance Precursor: Acts as an intermediate for specialized esters and amides in high-value chemical sectors.
• Material Science Research: Utilized in the development of novel polymers and liquid crystals with specific chiral properties.

Basic Information

Product Name	(R)-2-Methylbutyric Acid Chloride-D3
CAS No.	1217722-29-6
Molecular Formula	C5H6D3ClO
Molecular Weight	123.58 g/mol (approx.)
Synonyms	(R)-2-Methylbutanoyl-d3 Chloride; (R)-2-Methylbutyryl-d3 Chloride; (2R)-2-Methylbutanoyl-d3 Chloride; (R)-2-Methylbutyric-d3 Acid Chloride; (R)-α-Methylbutyryl-d3 Chloride; (R)-Active Ester-d3; Deuterated (R)-2-Methylbutyryl Chloride
EINECS	Contact for details

Quality Control

Our (R)-2-Methylbutyric Acid Chloride-D3 is manufactured under strict quality systems to ensure high chiral purity and isotopic enrichment. Each batch is characterized by advanced analytical techniques including chiral HPLC, NMR (1H, 13C), and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess (ee), deuterium incorporation, and impurity profiles, supporting compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.