Description

S-3-Cbz-Amino Pyrrolidine-Hcl is a high-purity, protected pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of a nitrogen-containing heterocycle, which is essential for constructing complex molecules with specific stereochemistry. This compound is particularly vital for pharmaceutical researchers and process chemists developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetics & PROTACs: Used to construct peptidomimetic scaffolds and as a linker component in Proteolysis Targeting Chimeras (PROTACs) due to its rigid pyrrolidine structure and protected amine.
• Agrochemical Synthesis: Employed in the synthesis of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	S-3-Cbz-Amino Pyrrolidine-Hcl
CAS No.	1217631-74-7
Molecular Formula	C₁₂H₁₆N₂O₂·HCl
Molecular Weight	256.73 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-3-aminopyrrolidine hydrochloride; (S)-3-(Cbz-Amino)pyrrolidine hydrochloride; (S)-N-Cbz-3-Aminopyrrolidine HCl; (S)-3-[(Benzyloxycarbonyl)amino]pyrrolidine hydrochloride; (3S)-3-[[(Phenylmethoxy)carbonyl]amino]-1-pyrrolidinecarboxylic acid hydrochloride; S-3-Cbz-NH-Pyrrolidine HCl; (S)-3-Amino-1-Cbz-pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of S-3-Cbz-Amino Pyrrolidine-Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, chiral analysis, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.