Description

5-Bromo-2-(3-(Trifluoromethyl)Phenyl)Pyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique molecular architecture, featuring both bromo and trifluoromethyl substituents, provides critical reactivity and lipophilicity for developing novel active compounds. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents. Its structural motifs are highly valued in medicinal chemistry for optimizing the pharmacokinetic properties of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands and organic electronic materials, such as those used in OLEDs.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) studies to explore and optimize the biological profile of lead compounds.
• Fluorine Chemistry: A valuable building block for introducing fluorine-containing motifs into molecules, a common strategy in modern drug design.

Basic Information

Product Name	5-Bromo-2-(3-(Trifluoromethyl)Phenyl)Pyridine
CAS No.	1215073-37-2
Molecular Formula	C12H7BrF3N
Molecular Weight	302.09 g/mol
Synonyms	5-Bromo-2-[3-(trifluoromethyl)phenyl]pyridine; 2-(3-(Trifluoromethyl)phenyl)-5-bromopyridine; 5-Bromo-2-(3-trifluoromethylphenyl)pyridine; 5-Bromo-2-(alpha,alpha,α-trifluoro-m-tolyl)pyridine; 1215073-37-2; 5-Br-2-(3-CF3-Ph)Py
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(3-(Trifluoromethyl)Phenyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.