Description

2-(Difluoromethoxy)Nicotinonitrile is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique difluoromethoxy-substituted nicotinonitrile structure makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Active Ingredient Development: Used in creating novel herbicides, fungicides, and insecticides where the difluoromethoxy group improves lipophilicity and target binding.
• Material Science Research: Serves as a precursor for fluorinated liquid crystals, organic semiconductors, and advanced polymers.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing enzyme inhibitors and molecular probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	2-(Difluoromethoxy)Nicotinonitrile
CAS No.	1214388-53-0
Molecular Formula	C7H4F2N2O
Molecular Weight	170.12 g/mol
Synonyms	2-(Difluoromethoxy)nicotinonitrile; Nicotinonitrile, 2-(difluoromethoxy)-; 3-Cyano-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-3-cyanopyridine; Pyridine, 3-cyano-2-(difluoromethoxy)-; 1214388-53-0; DFMN
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.