Description

3-Chloro-5-Fluoro-Isonicotinic Acid Methyl Ester is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a critical, structurally defined scaffold for introducing both chloro and fluoro substituents onto a pyridine core, enabling precise molecular design. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the halogenated pyridine moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers used in specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific halogenated isonicotinate derivatives.

Basic Information

Product Name	3-Chloro-5-Fluoro-Isonicotinic Acid Methyl Ester
CAS No.	1214385-88-2
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 3-Chloro-5-fluoropyridine-4-carboxylate; 3-Chloro-5-fluoro-4-pyridinecarboxylic acid methyl ester; 3-Chloro-5-fluoropyridine-4-carboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 3-chloro-5-fluoro-, methyl ester; Isonicotinic acid, 3-chloro-5-fluoro-, methyl ester
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-Isonicotinic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.