Description

3-Chloro-2-(3-Fluorophenyl)-5-Iodopyridine is a high-purity, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and iodine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the creation of organic electronic materials, ligands for catalysis, and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide excellent handles for Suzuki, Stille, and Negishi cross-coupling reactions.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by introducing halogen atoms at specific positions on the pyridine core.
• Chemical Library Development: A valuable scaffold for constructing diverse compound libraries for high-throughput screening.

Basic Information

Product Name	3-Chloro-2-(3-Fluorophenyl)-5-Iodopyridine
CAS No.	1214384-24-3
Molecular Formula	C11H6ClFIN
Molecular Weight	333.52 g/mol
Synonyms	3-Chloro-2-(3-fluorophenyl)-5-iodopyridine; 5-Iodo-3-chloro-2-(3-fluorophenyl)pyridine; 2-(3-Fluorophenyl)-3-chloro-5-iodopyridine; Pyridine, 3-chloro-2-(3-fluorophenyl)-5-iodo-; 1214384-24-3; 3-Chloro-2-(3-fluorophenyl)-5-iodo-pyridine; AKOS025244009; A-9234
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-(3-Fluorophenyl)-5-Iodopyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.