Description

4-Cyano-3-(trifluoromethyl)pyridine is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with both a cyano and a trifluoromethyl group. This unique molecular structure makes it a critical intermediate for the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for its ability to enhance metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Fluorine Chemistry Building Block: An essential compound for introducing the trifluoromethylpyridine moiety into more complex molecular architectures in medicinal and synthetic chemistry.

Basic Information

Product Name	4-Cyano-3-(trifluoromethyl)pyridine
CAS No.	1214383-56-8
Molecular Formula	C7H3F3N2
Molecular Weight	172.11 g/mol
Synonyms	3-(Trifluoromethyl)pyridine-4-carbonitrile; 4-Cyano-3-trifluoromethylpyridine; 3-Trifluoromethyl-4-cyanopyridine; 4-CN-3-CF3-Pyridine; Pyridine, 4-cyano-3-(trifluoromethyl)-; 4-Cyano-3-(trifluoromethyl)pyridine; 1214383-56-8
EINECS	Contact for details

Quality Control

Our 4-Cyano-3-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.