Description

2-(Difluoromethoxy)-4,6-Dimethylpyridine is a specialized fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethoxy group, which is crucial for modulating the physicochemical properties of target molecules. This intermediate is primarily required by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are desired.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy moiety can improve biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel nitrogen-containing ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of specialty chemicals, such as liquid crystals or organic electronic materials, due to its structural motif.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-(Difluoromethoxy)-4,6-Dimethylpyridine
CAS No.	1214379-04-0
Molecular Formula	C8H9F2NO
Molecular Weight	173.16 g/mol
Synonyms	4,6-Dimethyl-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-4,6-lutidine; 4,6-Dimethylpyridin-2-yl difluoromethyl ether; Difluoromethoxy-4,6-dimethylpyridine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-4,6-Dimethylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. We support our partners in the pharmaceutical supply chain with the necessary documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.